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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ESCO2
All Species:
5.76
Human Site:
S184
Identified Species:
15.83
UniProt:
Q56NI9
Number Species:
8
Phosphosite Substitution
Charge Score:
-0.13
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q56NI9
NP_001017420.1
601
68307
S184
E
K
E
N
N
C
H
S
A
E
N
N
S
N
A
Chimpanzee
Pan troglodytes
Rhesus Macaque
Macaca mulatta
Dog
Lupus familis
XP_543224
598
67974
S187
E
K
E
N
N
Y
Y
S
A
Q
D
N
L
N
A
Cat
Felis silvestris
Mouse
Mus musculus
Q8CIB9
592
67255
A194
Q
E
N
S
C
F
P
A
K
N
Y
P
N
S
P
Rat
Rattus norvegicus
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001508920
682
76075
P233
D
T
R
P
A
F
D
P
A
K
K
A
L
S
K
Chicken
Gallus gallus
XP_420012
679
73766
S241
L
I
K
K
K
M
D
S
P
F
R
V
L
S
M
Frog
Xenopus laevis
NP_001089603
640
69941
S197
P
E
P
E
E
T
T
S
V
L
S
M
K
T
T
Zebra Danio
Brachydanio rerio
Q5SPR8
609
68341
A190
K
P
K
L
V
V
G
A
A
F
F
N
T
G
K
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_791750
838
93461
R251
K
E
A
Q
V
E
R
R
S
S
P
R
K
L
V
Poplar Tree
Populus trichocarpa
Maize
Zea mays
NP_001146746
323
35496
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
N.A.
N.A.
74.2
N.A.
69
N.A.
N.A.
45.8
37.4
36.7
37.4
N.A.
N.A.
N.A.
N.A.
27.9
Protein Similarity:
100
N.A.
N.A.
84.1
N.A.
80
N.A.
N.A.
60.4
53.4
51.5
53.5
N.A.
N.A.
N.A.
N.A.
43
P-Site Identity:
100
N.A.
N.A.
66.6
N.A.
0
N.A.
N.A.
6.6
6.6
6.6
13.3
N.A.
N.A.
N.A.
N.A.
0
P-Site Similarity:
100
N.A.
N.A.
86.6
N.A.
40
N.A.
N.A.
26.6
20
20
40
N.A.
N.A.
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
21.6
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
31.2
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
0
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
0
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
0
12
0
12
0
0
23
45
0
0
12
0
0
23
% A
% Cys:
0
0
0
0
12
12
0
0
0
0
0
0
0
0
0
% C
% Asp:
12
0
0
0
0
0
23
0
0
0
12
0
0
0
0
% D
% Glu:
23
34
23
12
12
12
0
0
0
12
0
0
0
0
0
% E
% Phe:
0
0
0
0
0
23
0
0
0
23
12
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
12
0
0
0
0
0
0
12
0
% G
% His:
0
0
0
0
0
0
12
0
0
0
0
0
0
0
0
% H
% Ile:
0
12
0
0
0
0
0
0
0
0
0
0
0
0
0
% I
% Lys:
23
23
23
12
12
0
0
0
12
12
12
0
23
0
23
% K
% Leu:
12
0
0
12
0
0
0
0
0
12
0
0
34
12
0
% L
% Met:
0
0
0
0
0
12
0
0
0
0
0
12
0
0
12
% M
% Asn:
0
0
12
23
23
0
0
0
0
12
12
34
12
23
0
% N
% Pro:
12
12
12
12
0
0
12
12
12
0
12
12
0
0
12
% P
% Gln:
12
0
0
12
0
0
0
0
0
12
0
0
0
0
0
% Q
% Arg:
0
0
12
0
0
0
12
12
0
0
12
12
0
0
0
% R
% Ser:
0
0
0
12
0
0
0
45
12
12
12
0
12
34
0
% S
% Thr:
0
12
0
0
0
12
12
0
0
0
0
0
12
12
12
% T
% Val:
0
0
0
0
23
12
0
0
12
0
0
12
0
0
12
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
12
12
0
0
0
12
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _